Essential Amino Acids for Hypoalbuminemia Caused by Low Protein Diets
Essential amino acids are amino acids that the body cannot produce on its own and must be obtained through diet or supplementation. These amino acids are the building blocks of proteins, including albumin.
In cases of hypoalbuminemia caused by low protein diets recommended for CKD (Chronic Kidney Disease), supplementing with certain essential amino acids may be beneficial.
Following essential amino acids may be helpful for individuals with CKD + Hypoalbuminemia:
- Leucine: Leucine is known to stimulate protein synthesis and may help support muscle protein synthesis, which is important for maintaining overall protein balance in the body.
- Isoleucine: Like leucine, isoleucine is involved in protein synthesis and may help support muscle health.
- Valine: Valine is another essential amino acid that plays a role in protein synthesis and muscle metabolism.
- Threonine: Threonine is involved in the formation of collagen and elastin, as well as in protein synthesis. Threonine is a precursor to glycine, an inhibitory neurotransmitter in the central nervous system.
- Histidine: Histidine is involved in the synthesis of histamine and is important for maintaining the pH balance in the body.
- Tryptophan: Tryptophan is a precursor for serotonin and niacin (vitamin B3), and it is involved in protein synthesis.
- Phenylalanine: Phenylalanine is a precursor for the neurotransmitters dopamine, norepinephrine, and epinephrine, and it is involved in protein synthesis.
- Methionine: Methionine is a precursor for various important molecules in the body and is involved in protein synthesis.
Keto analogs of the branched-chain amino acids (leucine, isoleucine, and valine) are primarily used in the management of Chronic Kidney Disease (CKD) owing to their vital roles in protein synthesis and metabolism. These three amino acids are recognized for their significant impact on nitrogen balance and uremic toxin production in individuals with CKD.
Keto analogs of amino acids, commonly referred to as 'keto acids', are a component of the therapeutic approach for CKD. However, it's important to note that not all essential amino acids have available keto analog supplements. The focus is often on the branched-chain amino acids due to their particular importance in CKD management.
Supplementing with essential amino acids may help support protein synthesis and improve albumin levels in individuals with hypoalbuminemia caused by low protein diets recommended for CKD. Apart from Keto acids, threonine is typically considered safer option. Methionine is listed last due to concerns about its potential conversion to homocysteine, which can be harmful to cardiovascular health when present in excess.
However, it's essential to consult with a competent healthcare provider, as s/he can provide personalized recommendations based on your health and medical history. S/he can also monitor your progress and adjust your treatment plan as needed.
Please refrain from regarding the information provided here as authoritative or final. It's advisable to cross-reference this content with other sources for accuracy.
First draft of this document was uploaded on: 6 April 2024.
This document was revised and again uploaded on: 27 April 2024.
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