When Did Spermidine Start Being Used as a Health Supplement?
Spermidine started being used as a health supplement in the 2010s, after studies showed it might support healthy aging, brain function, and heart and kidney health.
Timeline of Spermidine as a Supplement:
- 2009–2015: Animal studies showed spermidine helped cells clean themselves (autophagy) and live longer. This created interest in its use for anti-aging.
→ Source: Eisenberg et al., Nature Cell Biology, 2009 Nov - Mid-2010s: A study found that people who ate more spermidine-rich foods had lower mortality rates.
→ Source: Kiechl et al., American Journal of Clinical Nutrition, 2018, Aug - 2016–2018: Supplements became available after public and scientific interest increased. Most were made from wheat germ.
→ Overview: Madeo et al., 2018 - 2020s: Spermidine gained popularity in longevity and wellness communities. It is now sold in capsules and powders as an over-the-counter supplement.
→ Summary: Zhou et al., Aging and Disease, 2021
Important Note:
Spermidine is not an approved medicine. While early research looks promising, more studies are needed to confirm how well it works and how safe it is for long-term use.
More info: Search "Spermidine" on PubMed
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First draft of this document was uploaded on: 21 April 2025.
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